No it is not. The TrueBlood novels--The Sookie Stackhouse series--was published in 2001 while Twilight was 2005. Twilight is written for young teenage girls while the TrueBlood series is for middle aged women.
However the t.v. series is vastly different from the novel as the creator Alan Ball just uses the characters + setting but has a different story. It appeals to mostly the 20-30 year old demographic and a lot of people on my campus view it. It's one of my favorite television shows.