Currently my all-time favorite anime/manga ship: Natsu/Lucy (Fairy Tail). Yes, they did end up together but it was how they ended up together that sucked!
My most severe reaction to it: NH and SS being canon is the main reason my Narutard self largely died out! I am hoping to finish up the Eng. dub by the end of the year and I do watch Boruto mainly to support the industry but also out of spite!