Not really. If Kushina will be a Yandere in the prequel, it will most likely be played for laughs. There's a difference. Unless, of course, Kishi moves the story to Monthly Jump Magazines like SQ.
I think yanderes are just mentally unstable people who looks innocent whenever she's around her love interest but turn psychotic killer when not. They are usually unrequited love and rarely used for comedic purposes. A tsundere would be the type for that.
Well, if you want a comedic version of Yanderes, here's one:
Haru to NatsuI personally think Kishimoto could actually pull off a a hilarious version of Yandere in Kushina.
I agree, he could pull it off pretty well, with her losing control occasionally when girls flirt with Minato. It's only that, with how little we saw of Kushina's past, and her relationship with Minato, the only thing I can really see in that regard is Kushina being a bit of a jealous tsundere. I'm not sure I can really see the whole psychotic aspect that Yandere seems to imply being displayed through Kushina. If it was, anyway, it'd be a lot lower than the 70% Y / 30% T ratio from your original comment.
I do agree though, that the idea is hilarious.
On the topic of Yandere characters, I'm looking at the TV Tropes article right now, and it looks I have seen it done a few times. They're all over the place in Code Geass, and I never really though of Loly and Menoly from Bleach as fitting that mold, but it certainly makes sense.
Also, there's an Alternate Character Interpretation of Loly of as a
Depraved Bisexual? That's interesting, LOL. It's no wonder people spend so much time on this site.

Usually yandere is not supposed to be funny because it is DISTURBING. You actually want to see that demented kind of love where one of the lovers uses bloody violence to to vent their jealousy or expressing their STRONG feelings for the one of their affections?

well It can only be FUNNY if it's toned down. You know, the blood and gore is comedic and the character is no so insane,but overall THIS WOULD BE a contradiction because If Kishimoto did that with Kushina it will HAVE TO happen with Naruto. SO next time that Nobody shinobi confesses to Sakura again or she thinks about Sasuke Naruto will go coo-coo and Brutally murder said admirer, Sasuke and then GUT Sakura because he HAS the Kyuubi; SOUND APPEALLING?
Edited by Phantom_999, 10 September 2011 - 09:50 PM.