I have a theory that Sasuke will die, but not before discovering that there are many other Uchihas out there, that come out of the woodwork in the end (like with the Uzumakis over the course of the manga - Karin, Nagato, the shrine, etc. There have been shown to be a few sprinkled around.). So that gets Sasuke off the hook for letting his clan die, and he can instead give his life to protect his friends in the end.
I'm even betting that there's a secret Uchiha enclave somewhere, that split off from the crazy one. A secret group that isn't cursed by the sharingan, but that keeps their identity hidden so they aren't tainted by association.
And at the end they come out to give Sasuke some support, helping him change to being a good/protective force. And he lives long enough to see them welcomed into Konoha and reestablishing the Uchiha name in the empty sector of Konoha that was once theirs. Maybe even with Sasuke deeding it to them as the sole heir of the clan's Konoha lands/holdings.
I just don't see Sasuke as having kids. Nothing in his storyline has hinted that he wants/will have a romance, a family and stable home-life in the future. Naruto is the one who wants those goals, and is set up to get them.
I think Sasuke will succeed in reestablishing his clan, but I don't think he will do it through his own line of children. I think if he knew that he could restart the clan but let the last of the sharingan users die with him, he'd do it.
I think that's a really interesting theory. I like it.