Again AHK?
Just look at what Orochimaru said, even if Tobirama didn't really wanted to isolate them, he ended up doing it
just look
Orochimaru is simply wrong. All you have to do is look at the story. The Uchiha that were loyal to Madara were rebelling before Tobirama was even Hokage, they started following him because his actions brought pride in them, when before hand they all ignored Madara's desires. Had Madara simply accepted the fact that his stupid Uchiha pride was outdated none of this would have happened. Because Madara rose up, and because the 1st didn't kill him outright the seeds were planted for the Uchiha's fall. The Uchiha's clans pride is what lead to their fall.
Secondly Orochimaru's excuse is just kitten insane if applied to any logical act, and he is seemingly saying it in order to alter the feelings of the kitten insane Sasuke. Police officers no matter how much they are disliked by elements of the public, aren't leading coups the world over. The Uchiha's problems are routed back to Madara and his actions, and their veneration of him. Without their stupid pride they never would have thought of themselves as "better then this". Had they simply learned to join together to prove their detractors wrong and instead had pride in the fact that they were equals to any other clan nothing would have happened to the Uchiha. But that isn't what the being an Uchiha is about. They are the elite, the best, the greatest. Who created that legend? Madara of course. The Uchiha were "to good" to be simple cops, and because of that they had a right and duty to their own supremacy to put themselves back on top where they belonged.
Which is the problem with the whole "clan" identification to begin with. Which is what this story was originally about. This story started about an orphan boy, who came from a family of no particular importance, rising up by hard work and self worth in order to challenge the ruinous established traditions. It's why Naruto is placed against Neji, Neji is the perfect representation of the ideals of the old order. Neji believes you are born into a certain family, a certain class, a certain occupation, and there is nothing you can do to change that. You must follow your fate to the end no matter the consequences, as such and to fight against it is to challenge the will of the Gods. Naruto on the other hand representing modernity, rejects these notions in order to defend the natural God given right of every human being, who rise and fall throughout society based on their own actions and deeds. You could even reject the labels your family put on you according the Naruto. Which is an idea Neji can't stand because his own father died because of the label his family placed on him.
What does this have to do with the Uchiha? Everything. The family were originally destroyed by an elitist kitten. At first we believed that Itachi murdered the clan for his own desire of power. Knowing that his strength increased by murdering his best friend, it was also hinted at that he murdered the clan so his power would continue to be concentrated further. Which is also why he allowed Sasuke to live. He needed him to become more powerful, and eventual reach a level near Itachi, so later Itachi could kill him for his eyes and become stronger yet.
In that story the Uchiha are massacred because of myths in their family tree, and they were destroyed from within because of those old cancerous ideals.
Then Itachi became Jesus, and instead the Uchiha were planning to rise on their own. Which completely destroyed the original theme of the story. Now the story was not about the rights of all people even the orphaned and abused like Naruto and Sasuke. It became about the importance of your birth. Naruto was great not because of how hard he worked, but ultimately because he was the son of the 4th. Hell this point is driven home when his dead father saves him. Sasuke? His "revenge" doesn't become directed towards one broken man, but instead towards the world itself, because "the Uchiha were better then where they were" and in fact were betrayed by one of their own. The Uchiha couldn't be stopped by "lesser" clans, oh no not the mighty Uhciha. It required that they be taken down by one of their own, so they also needed to be avenged by one of their own.
Then it gets worst. Naruto and Sasuke are reincarnated royal brothers. You see this whole time their actions and in fact entire lives have been directed by the actions of their former selves. They aren't only living out their own fate, they have no other options but to live out their own fates. Why is this time going to be different? Simple it's destined to be different this time, because they failed before hand.
What does this have to do with Oro's talk about the Uchiha? Well in my mind it's obvious. The Uchiha being the victims only makes sense if the you accept that the story is completely broken down from the start, and the alterations were planted long ago that eventually would break the story. The Uchiha can be many things, but victims who had no real choice in their destiny is not one of them. Which is the main problem with the idea of the Uchiha rebelling. This story made much more sense theme wise in part one.
So then we must come to one simple conclusion, a conclusion that Kishimoto doesn't want us to pick up on. The Uchiha brought this all upon themselves in the end. Well Kishimoto can't have that can he? After all Sasuke is to big of a draw, and he wants to tell a story about forgiveness. So what does he do? He comes up with this stupid storyline about how they were being oppressed, because they were so much better then their station in life. Why are they so important? Because they are the great Uchiha clan, they founded the village, but their lessers feared them so they tried to contain their greatness! They are better then mere police officers. The Uchiha are born to rule, not be simple civil servants!
Which is why this is a broken story. It started as a story about the dignity of all people no matter who they are, and ended up being about the importance of the station you were born into. The theme was flipped on it's head half way threw the story, which is why this "Uchiha are just victims", feels like complete kitten to so many of us. It makes no sense in this world as it has been set up. The story worked much better when the Uchiha were destroyed from within because of their clans legends. When Kishimoto attempted to put the blame on "the system" he broke the moral of his story. Especially when in the end "the system" isn't changed at all, Naruto keeps things the way they always were he simply leads it now. Why did Sasuke stop fighting? Was it because Naruto showed him that the system works? Nope, it was because Naruto punched him really hard, and Sasuke loves him to much.
To complete untangle the problems with this story would take to long, but the Uchiha being "victims" is a huge part of it. They can't be "victims" because their actions are what lead to their downfall, actions they freely choose. They choose to take over the village simply because of their own arrogance, and belief in their superiority, that they are much better then what the village thinks of them. An idea that was originally rejected in this very same story earlier on, but later we are suppose to relate to the Uchiha's struggles. Why? Who knows. Kishimoto makes it perfectly clear the the legends and customs of the Hyuga clan are outdate, anti human, and disgusting. The Uchiha legends and customs though? They are somehow "honorable" and worthy of death, well the system around them (the belief in individuals coming together for the village) is what is disgusting. Well you can't have it both ways. Either individuality is what is important or your destiny is what is important you can't have both. In the end we get this strange "right of kings" style of message with Naruto and Sasuke being the eternal princes who decide the fate of the universe because it is their choice to make by a birthright that happened in their former lives.
Free will vs destiny was one of the corner stones of this story. The fact that it was flipped on it's head in the end is the huge fault line in this tale, and in the end that starts largely as a way to excuse the actions of the Uchiha clan, and by extension of course to excuse the actions of Sasuke Uchiha.