Couple of thoughts I had:
Since the cloud nin were looking for someone to talk to, it seems fairly likely they'll be doing so next chapter... I'm really interested in that. Wasn't Killerbee (or however you wanna spell it) their sensei? Their reaction to Naruto might be interesting, and also, seeing as people have been talking about Killerbee teaching Naruto, would it be possible
they could know something to teach him? I'm rambling a bit... just a vague possibility. More interesting from a NaruSaku point of view... I feel like Sakura finding out Sasuke has joined Akatsuki might be a moment to throw her feelings into stark clarity... maybe. And of course, Sasuke on his way to Konoha at the same time (with Cloud hanging round wanting him dead)... things are going to be very interesting. I smell Development.
*Slightly off-topic - Anyone else appreciate how excessively evil Sasuke looked at the end of 449? Naruto has a new grown-up-wise look (that panel when he said 'Tsunade...' in this chapter

), I guess Sasuke has a new 'villain' look too.
We'll see, it'll be interesting.
As for Akatsuki, well, that's gonna be a decent sized bombshell for Naruto and Sakura. I don't think Naruto is gonna believe it until he sees it; Sakura might expect it.
And yes, I would appreciate a villain Sasuke XD.